6-Bromo-2-pyridinemethanamine hydrochloride

6-Bromo-2-pyridinemethanamine hydrochloride - Names and Identifiers

Name	6-Bromo-2-pyridinemethanamine hydrochloride
Synonyms	(6-BROMOPYRIDIN-2-YL)METHANAMINE HCL 6-BROMO-2-PYRIDINEMETHANAMINEHCLSALT 6-bromo-2-pyridinemethanamine hydrochL 6-Bromo-2-pyridinemethanamine hydrochloride 6-BROMO-2-PYRIDINEMETHANAMINE, HYDROCHLORIDE (6-Bromo-2-pyridyl)methanamine hydrochloride C-(6-Bromo-pyridin-2-yl)-methylamine dihydrochloride
CAS	914947-26-5
InChI	InChI=1/C6H7BrN2.ClH/c7-6-3-1-2-5(4-8)9-6;/h1-3H,4,8H2;1H

6-Bromo-2-pyridinemethanamine hydrochloride - Physico-chemical Properties

Molecular Formula	C6H8BrClN2
Molar Mass	223.5
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

6-Bromo-2-pyridinemethanamine hydrochloride - Risk and Safety

Hazard Symbols	T - Toxic
Risk Codes	25 - Toxic if swallowed
Safety Description	45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

6-Bromo-2-pyridinemethanamine hydrochloride - Reference Information

Use

6-bromo-2-picolylamine hydrochloride is in the form of 6-bromo-2-picolylamine hydrochloride, 6-bromo-2-picolylamine is an important organic intermediate, which can be prepared from 2-bromo-6-hydroxymethylpyridine, can be used in laboratory research and development process and chemical and pharmaceutical synthesis process.

preparation

2- [(6-bromopyridin-2-yl) methyl] -2, 3-dihydro-1h-isoindole-1, 3-dione (2.5g,7.88mmol,1.0 equiv) in absolute ethanol (78ml), A 250ml round bottom flask equipped with a magnetic stir bar and condenser was loaded and heated to reflux until complete dissolution (approximately 15 minutes). To the homogeneous solution was added hydrazine monohydrate (1.58g,1.53mL,31.53mmol,4.0 equiv). Within one minute, the reaction mixture turned yellow. The reaction mixture was heated for 3 hours during which time the mixture solidified into a thick white suspension. Another 50ml of ethanol was added and the mixture was stirred for an additional 2 hours. The reaction was cooled to room temperature and then to 0 °c to precipitate the hydrazine/phthalimide adduct that disintegrated in solution. The precipitate was filtered on Buchner. The precipitate was thoroughly washed with absolute ethanol, and the filtrate was partially concentrated. There was still some solids in the suspension, which was then filtered with cold EtOH. The filtrate was concentrated to dryness to give a solid.

Last Update：2024-04-09 15:16:53